- Reason 9.5 and later supports 64-bit VST2 (2.4) plugins
- Reason 12.5 and later supports 64-bit VST3 and VST2 plugins
- 32-bit VST plugins are not supported.
- VSTs that output MIDI are not supported in Reason.
- Multitimbral VSTs (that can receive on separate MIDI channels) are not supported. You will then have to use one instance of the VST for each sound/channel.